Transformation of saturated nitrogen-containing heterocyclic compounds by microorganisms

The saturated nitrogen-containing heterocyclic compounds include many drugs and compounds that may be used as synthons for the synthesis of other pharmacologically active substances. The need for new derivatives of saturated nitrogen-containing heterocycles for organic synthesis, biotechnology and the pharmaceutical industry, including optically active derivatives, has increased interest in microbial synthesis. This review provides an overview of microbial technologies that can be valuable to produce new derivatives of saturated nitrogen-containing heterocycles, including hydroxylated derivatives. The chemo-, regio- and enantioselectivity of microbial processes can be indispensable for the synthesis of new compounds. Microbial processes carried out with fungi, including Beauveria bassiana, Cunninghamella verticillata, Penicillium simplicissimum, Aspergillus niger and Saccharomyces cerevisiae, and bacteria, including Pseudomonas sp., Sphingomonas sp. and Rhodococcus erythropolis, biotransform many substrates efficiently. Among the biological activities of saturated nitrogen-containing heterocyclic compounds are antimicrobial, antitumor, antihypertensive and anti-HIV activities; some derivatives are effective for the treatment and prevention of malaria and trypanosomiasis, and others are potent glycosidase inhibitors.
http://dx.doi.org/10.1007/s00253-013-5429-1

Platypus - is a furry animal

Platypus - is a furry animal with a duck's beak that lives in Australia. In itself it is neither a duck nor beast, and the presence of duck beak of this animal is very unusual fact. In the platypus a broad, rubbery beak, which resembles a duck, swims platypus as beaver, and lays eggs like a turtle. The platypus can jetted toxic poison, like a reptile.
Platypus

Scientific Social Network - mendeley.com

The best free way to manage your research - organize, share, discover - THERE

Int. J. Nanobiotechnol. Pharm.

Articles of  Int. J. Nanobiotechnol. Pharm. are distributed worldwide by Mail Services and with help of annual subscription or purchasing single copy. THERE

Microbiology, biotechnology and biochemistry

The using of microbial enzymes in the area of chemical, biotechnological and pharmacological industries has been carried out for a long time. HERE

Separating molecules, but uniting people

Problems of development of chemistry as a science are reflected in the new monographs replenished funds Information and Library Center of Tyumen State University . March 21, 1903 Russian scientist, Professor Mikhail Tsvet (1872-1919) at the meeting of the Warsaw Society of Naturalists first introduced in the scientific speech the term "chromatography" — a dynamic method for the separation and analysis of mixtures of substances.
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